Intercellular Communication in the Lens and Retinal Glial cells
Education
PhD, , University of Florida College of Medicine,
PhD, Doctor of Optometry, University of Florida College of Medicine,
Publications
Myopia Alters the Structural Organization of the Retinal Vasculature, GFAP-Positive Glia, and Ganglion Cell Layer Thickness, International Journal of Molecular Sciences 23 (11): 6202 6202, 2022
Suppression of connexin 43 phosphorylation promotes astrocyte survival and vascular regeneration in proliferative retinopathy., Proceedings of the National Academy of Sciences of the United States of America 115 (26): E5934-E5943 E5934-E5943, 2018
Human diseases associated with connexin mutations., Biochimica et biophysica acta 1860 (1): 192-201 192-201, 2018
Identification and Functional Assessment of Age-Dependent Truncations to Cx46 and Cx50 in the Human Lens., Investigative ophthalmology & visual science 57 (13): 5714-5722 5714-5722, 2016
Syndromic deafness mutations at Asn 14 differentially alter the open stability of Cx26 hemichannels., The Journal of general physiology 148 (1): 25-42 25-42, 2016
Aberrant connexin26 hemichannels underlying keratitis-ichthyosis-deafness syndrome are potently inhibited by mefloquine., The Journal of investigative dermatology 135 (4): 1033-1042 1033-1042, 2015
Connexin 46 (cx46) gap junctions provide a pathway for the delivery of glutathione to the lens nucleus., The Journal of biological chemistry 289 (47): 32694-702 32694-702, 2014
Altered inhibition of Cx26 hemichannels by pH and Zn2+ in the A40V mutation associated with keratitis-ichthyosis-deafness syndrome., The Journal of biological chemistry 289 (31): 21519-32 21519-32, 2014
Functional effects of Cx50 mutations associated with congenital cataracts., American journal of physiology. Cell physiology 306 (3): C212-20 C212-20, 2014
Connexin channel modulators and their mechanisms of action., Neuropharmacology 75 517-24 517-24, 2013
The D50N mutation and syndromic deafness: altered Cx26 hemichannel properties caused by effects on the pore and intersubunit interactions., The Journal of general physiology 142 (1): 3-22 3-22, 2013
The N-terminal half of the connexin protein contains the core elements of the pore and voltage gates., The Journal of membrane biology 245 (8): 453-63 453-63, 2012
Triarylmethanes, a new class of cx50 inhibitors., Frontiers in pharmacology 3 106 106, 2012
Connexin43 mutation causes heterogeneous gap junction loss and sudden infant death., Circulation 125 (3): 474-81 474-81, 2012
Mechanism of inhibition of connexin channels by the quinine derivative N-benzylquininium., The Journal of general physiology 139 (1): 69-82 69-82, 2012
Differentially altered Ca2+ regulation and Ca2+ permeability in Cx26 hemichannels formed by the A40V and G45E mutations that cause keratitis ichthyosis deafness syndrome., The Journal of general physiology 136 (1): 47-62 47-62, 2010
Interaction between Connexin50 and mitogen-activated protein kinase signaling in lens homeostasis., Molecular biology of the cell 20 (10): 2582-92 2582-92, 2009
Loop gating of connexin hemichannels involves movement of pore-lining residues in the first extracellular loop domain., The Journal of biological chemistry 284 (7): 4484-93 4484-93, 2009
Divalent cations regulate connexin hemichannels by modulating intrinsic voltage-dependent gating., The Journal of general physiology 132 (3): 315-27 315-27, 2008
Optimal lens epithelial cell proliferation is dependent on the connexin isoform providing gap junctional coupling., Investigative ophthalmology & visual science 48 (12): 5630-7 5630-7, 2007
Block of specific gap junction channel subtypes by 2-aminoethoxydiphenyl borate (2-APB)., The Journal of pharmacology and experimental therapeutics 319 (3): 1452-8 1452-8, 2006
Functional characterization of a naturally occurring Cx50 truncation., Investigative ophthalmology & visual science 47 (10): 4474-81 4474-81, 2006
Mefloquine effects on the lens suggest cooperative gating of gap junction channels., The Journal of membrane biology 211 (3): 163-71 163-71, 2006
Regulation of connexin hemichannels by monovalent cations., The Journal of general physiology 127 (1): 67-75 67-75, 2006
Transfection of mammalian cells with connexins and measurement of voltage sensitivity of their gap junctions., Nature protocols 1 (4): 1799-809 1799-809, 2006
New possible roles for aquaporin-4 in astrocytes: cell cytoskeleton and functional relationship with connexin43., FASEB journal : official publication of the Federation of American Societies for Experimental Biology 19 (12): 1674-6 1674-6, 2005
Correlative studies of gating in Cx46 and Cx50 hemichannels and gap junction channels., Biophysical journal 88 (3): 1725-39 1725-39, 2005
Potent block of Cx36 and Cx50 gap junction channels by mefloquine., Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12364-9 12364-9, 2004
Molecular cloning and functional expression of zfCx52.6: a novel connexin with hemichannel-forming properties expressed in horizontal cells of the zebrafish retina., The Journal of biological chemistry 279 (4): 2913-21 2913-21, 2004
Closure of gap junction channels by arylaminobenzoates., Molecular pharmacology 63 (6): 1389-97 1389-97, 2003
Prospects for rational development of pharmacological gap junction channel blockers., Current drug targets 3 (6): 455-64 455-64, 2002
Virtual cloning, functional expression, and gating analysis of human connexin31.9., American journal of physiology. Cell physiology 283 (3): C960-70 C960-70, 2002
Evidence for a role of the N-terminal domain in subcellular localization of the neuronal connexin36 (Cx36)., Journal of neuroscience research 69 (4): 448-65 448-65, 2002
Growth-suppressive function of human connexin32 in a conditional immortalized mouse hepatocyte cell line., In vitro cellular & developmental biology. Animal 37 (9): 589-98 589-98, 2001
Quinine blocks specific gap junction channel subtypes., Proceedings of the National Academy of Sciences of the United States of America 98 (19): 10942-7 10942-7, 2001
Calmodulin kinase pathway mediates the K+-induced increase in Gap junctional communication between mouse spinal cord astrocytes., The Journal of neuroscience : the official journal of the Society for Neuroscience 21 (17): 6635-43 6635-43, 2001
How to close a gap junction channel. Efficacies and potencies of uncoupling agents., Methods in molecular biology (Clifton, N.J.) 154 447-76 447-76, 2001
Identification and functional expression of HCx31.9, a novel gap junction gene., Cell communication & adhesion 8 (4-6): 173-8 173-8, 2001
Molecular and functional diversity of neural connexins in the retina., The Journal of neuroscience : the official journal of the Society for Neuroscience 20 (22): 8331-43 8331-43, 2000
Properties of gap junction channels formed by Cx46 alone and in combination with Cx50., Biophysical journal 79 (4): 1954-66 1954-66, 2000
Voltage gating properties of channels formed by a skate retinal connexin., The Biological bulletin 199 (2): 165-8 165-8, 2000
Temporal expression of neuronal connexins during hippocampal ontogeny., Brain research. Brain research reviews 32 (1): 57-71 57-71, 2000
TPA induced expression and function of human connexin 26 by post-translational mechanisms in stably transfected neuroblastoma cells., Cell structure and function 24 (6): 435-41 435-41, 1999
Functional properties of channels formed by the neuronal gap junction protein connexin36., The Journal of neuroscience : the official journal of the Society for Neuroscience 19 (22): 9848-55 9848-55, 1999
Voltage dependence of macroscopic and unitary currents of gap junction channels formed by mouse connexin50 expressed in rat neuroblastoma cells., The Journal of physiology 517 ( Pt 3) 673-89 673-89, 1999
